Cisplatin and hyponatremia

Author: swam

August undefined, 2024

WebJan 13, 2024 · In addition, significant hyponatremia signals were detected for oesophageal, lung, and renal cancers. Conclusions: Hyponatremia has been reported in women and patients with lung cancer... WebThe incidence of hyponatremia secondary to cisplatin can be as high as 43%, [ 6] the mechanism of action by which cisplatin induces hyponatremia is controversial. There …

Overview of the treatment of hyponatremia in adults - UpToDate

WebApr 6, 2024 · Treatment-related grade 3/4 hyponatremia was reported in 5%–7% of MIBC patients treated with pre-operative ... NAC and prolonged survival. 34-36 It is hypothesized that these mutations may increase the sensitivity of tumor cells to cisplatin-induced DNA damage, thereby enhancing the drug's efficacy in these tumors. 37 The incidence of DDR ... WebMar 1, 2024 · Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. rcoa physics

Electrolyte disorders with platinum-based chemotherapy …

WebHyponatremia is one of the common electrolyte disorders associated with cisplatin (CDDP) administration. We report here two cases of hyponatremia associated with CDDP. Case 1 : A 75-year-old man with urothelial carcinoma of bladder (cT3N1M0) underwent neoadjuvant chemotherapy with CDDP and gemcitabi … WebNov 10, 2024 · A phase I clinical trial of cisplatin and dose-escalating crolibulin was conducted in patients with advanced solid cancers, including recurrent or metastatic ATC. Of 16 patients with ATC, there was one patient with a complete response and one with stable disease. ... (33%), hyponatremia (29%), anemia (19%), hypertension during infusion … WebSep 15, 2024 · Serum Electrolyte Disturbances - Hypomagnesemia, hypocalcemia, hyponatremia , hypokalemia, and hypophosphatemia have been reported to occur in patients treated with cisplatin (cisplatin injection) and are probably related to renal tubular damage. Tetany has occasionally been reported in those patients with hypocalcemia and … rcoa stage 1 procedures

DailyMed - SPIRONOLACTONE tablet SPIRONOLACTONE tablet, …

Management of Hyponatremia AAFP

WebFeb 16, 2024 · were treated with cisplatin for various cancers, 8.9% and 1.7% developed grade 3 (serum sodium 120–129mEq/L) and grade 4 ( WebJan 1, 2024 · Univariable analysis revealed a high incidence of hyponatremia in patients receiving cisplatin, three-drug combination regimen, two-drug combination regimen with … simsbury seniorsWebBecause hyponatremia was not observed in the subsequent cycle of chemotherapy consisting of weekly paclitaxel and cisplatin, carboplatin was thought to be responsible for the condition. Clinicians should be aware of the possibility that carboplatin may cause SIADH, and should carefully monitor electrolyte balance after chemotherapy. simsbury sctv

"WebMar 24, 2024 · Carboplatin and oxaliplatin may have a lower incidence of hyponatremia relative to cisplatin containing regimens. 10 Of course, malignancy-specific risks of … " - Cisplatin and hyponatremia

Cisplatin and hyponatremia

Cancers Free Full-Text The Onco-Nephrology Field: The Role of ...

WebHyponatremia of grade 3 or above developed in 30.7% of the generic CDDP group compared to 15.1% of the brand-name CDDP group ( P =0.011). Multivariate analysis … Webcisplatin It is a treatment for a number of different types of cancer. How GC works These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. How you have GC You have these drugs into your bloodstream (intravenously). You might have treatment through a long plastic tube that goes into a large vein in your chest.

Did you know?

WebJun 11, 2024 · INTRODUCTION Hyponatremia represents a relative excess of water in relation to sodium. It can be induced by a marked increase in water intake (primary polydipsia) and/or by impaired water excretion due, for example, to advanced kidney failure or persistent release of antidiuretic hormone (ADH). (See "Causes of hypotonic … WebNational Center for Biotechnology Information

WebJan 27, 2024 · Urothelial cancer of the bladder, renal pelvis, ureter, and other urinary organs is the fifth most common cancer in the United States, and systemic platinum-based chemotherapy remains the standard of care for first-line treatment of advanced/metastatic urothelial carcinoma (UC). Until recently, there were very limited options for patients who … Webmostly solid tumors had hyponatremia, and of these, 11% had moderate (sodium [Na] 120–129 mEq/L) to severe (Na , 120 mEq/L) hyponatremia (1). This is disproportionately higher than the hyponatremia prevalence rates of 15%–30% reported for general medicine admissions (2). In cancer patients with nonsolid tumors, rates of hyponatremia are less.

WebJun 2, 2024 · Background: Cisplatin-associated acute kidney injury (C-AKI) is common. Predictive factors of C-AKI include age > 60 years, hypertension, cisplatin dose, … WebNov 12, 2024 · Very common (10% or more): Anorexia, hyponatremia Uncommon (0.1% to 1%): Hypomagnesemia Frequency not reported: Dehydration, hypokalemia, …

WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum …

WebSep 1, 2002 · (6) The mechanism of cisplatin-induced hyponatremia is thought to be mainly renal salt wasting syndrome (RSWS), (7) (8) (9) (10) (11) (12) (13) and sometimes the syndrome of inappropriate... rcoa researchWebDec 3, 2014 · Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation Drug Des Devel Ther doi: 10.2147/DDDT.S71419. eCollection 2014. Authors rcoa safetyWebJul 8, 2010 · However, less commonly known is that cisplatin can cause hyponatremia. SIADH is commonly blamed for the cause of hyponatremia in the setting of a patient with … rcoa stage 3 trainingWebcisplatin, docetaxel and 5-fluorouracil-containing chemotherapy who suffered from acute-onset consciousness disturbance due to hyponatremia just after administration of … simsbury senior center classesWebCisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome. A treatment strategy that incorporates both water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. rcoa senior fellows clubWebMay 17, 2024 · If you have moderate, chronic hyponatremia due to your diet, diuretics or drinking too much water, your doctor may recommend temporarily cutting back on fluids. … rcoa st5 top upWebHyponatremia is a common potential complication in cancer patients. It can be related to anticancer medical therapy. Vincristine, vinblastine, cisplatin and cyclophosphamide are the chemotherapeutic agents most frequently associated with hyponatremia. More recently, analogs such as carboplatin and ifosfamide have also been incriminated. simsbury senior housing