WebSemantic Scholar extracted view of "Role of CD4+ T lymphocytes in antitumor immunity." by E. Rajnavölgyi et al. WebCD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF), and its mRNA is known to be expressed in HSCs. Here, we demonstrate that mice lacking CD74...

MIF promotes B cell chemotaxis through the receptors CXCR4 and …

WebCD74, also known as CLIP, is a 33.5kD homotrimer and functions as a MHC class II chaperone for exogenous peptides and other MHC class II molecules. CD74 binds MIF and regulates innate and adaptive immunity through CD44 signaling. It is found primarily on B-cells, monocytes, macrophages and dendritic Webphosphorylation of CD74 and CD44. Investigations that used siRNA or kinase inhibitors indicate that MIF-induced ERK1 and ERK2 activation through CD44 required the Src tyrosine kinase. Studies of CD74,CD44,andCD74-CD44transformantsandcorre-sponding mutant cells showed that CD74 and CD44 were necessary for MIF protection from … spa waynesville nc

A deficient MIF-CD74 signaling pathway may play an important

WebCD74 is a surface receptor for MIF. [9] Bacterial antigens stimulate white blood cells to release MIF into the blood stream. [10] The circulating MIF binds to CD74 on other immune cells to trigger an acute immune response. Hence, MIF … WebAbstract. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that plays a role in innate and adaptive immunity. Depending on the cellular context and disease … WebAt the molecular level, these activities are based on a non-cognate interaction between MIF and the CXC chemokine receptors CXCR2 and CXCR4. Importantly, MIF also interacts with surface CD74, a type II transmembrane protein, inducing its phosphorylation and the recruitment of CD44, leading ultimately to ERK1/2 phosphorylation. spaw cork